THE NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES (NIGMS) could be considered a ï¿½Nobel Prize Instituteï¿½ because of its strong track record of funding scientists who receive this high honor. These investigators perform cutting-edge basic research that is the foundation for understanding normal life processes and disease. Nobel Prizes and other awards recognize the breadth and significance of these findings.
To date, NIGMS has funded the Nobel Prize-winning work of 80 scientists. Among their discoveries:
- Translating the genetic code of DNA and explaining how it functions in the production of protein in the cell.
Robert W. Holley and H. Gobind Khorana (shared with Marshall W. Nirenberg)
- Defining the internal organization of cells using electron microscopy and other techniques, which laid the foundation for understanding key cellular pathways and processes.
George E. Palade and Christian de Duve (shared with Albert Claude)
- Finding that RNA can act as a catalyst, controlling and directing cellular functions.
Thomas Cech and Sidney Altman
- Discovering restriction enzymes, which cut DNA at precise locations and are a cornerstone of recombinant DNA technology.
Hamilton O. Smith and Daniel Nathans (shared with Werner Arber)
- Identifying proteins that trigger a cellï¿½s response to outside signals and are involved in normal activities as well as diseases like cancer, cholera and diabetes.
Alfred G. Gilman (shared with Martin Rodbell)
These and other important breakthroughs in chemistry and biology often lead to more focused research that culminates years later in important medical advances or commercial products such as medicines or biotechnology tools.
RECENT NOBEL LAUREATES SUPPORTED BY NIGMS
|Martin Karplus, Michael Levitt & Arieh Warshel
||For the development of multiscale models for complex chemical systems|
|James E. Rothman & Randy W. Schekman
||Physiology or Medicine 2013
||For their discoveries of machinery regulating vesicle traffic, a major transport system in our cells|
|Brian K. Kobilka
||For studies of G-protein-coupled receptors|
||For palladium-catalyzed cross couplings in organic synthesis|
Thomas A. Steitz &
Ada E. Yonath
||For studies of the structure and function of the ribosome|
|Elizabeth H. Blackburn,
Carol W. Greider &
Jack W. Szostak
|Physiology or Medicine 2009
||For the discovery of how chromosomes are protected by telomeres and the enzyme telomerase|
Martin Chalfie &
Roger Y. Tsien
||For the discovery and development of the green fluorescent protein, GFP|
|Mario R. Capecchi &
|Physiology or Medicine 2007
||For the discovery of principles for introducing specific gene modifications in mice by the use of embryonic stem cells|
|Roger D. Kornberg
||For his studies of the molecular basis of eukaryotic transcription|
|Andrew Z. Fire &
Craig C. Mello
|Physiology or Medicine 2006
||For the discovery of RNA interferenceï¿½gene silencing by double-stranded RNA|
|Robert H. Grubbs & Richard R. Schrock
||For the development of the metathesis method in organic synthesis [a chemical reaction for making carbon-carbon bonds]|
A full list of NIGMS-supported Nobel Prize winners and links to news releases about their work, is available at http://www.nigms.nih.gov/pages/GMNobelists.aspx
Crossword Puzzle: Test Your Nobel Knowledge | Accessible Version
Roderick MacKinnon, Rockefeller University
Cells don't let just anything slip past their external membranes. Instead, protein channels control the passage of most substances, including the ions that allow nerves to signal, muscles to flex and hormones to be secreted in an orderly way. For more than a century, chemists have understood that the flow of ions across membranes could produce electrical signals. But exactly how ion channels work has only been known since 1998, when Roderick MacKinnon showed for the first time what these proteins look like at the atomic level. This was such a fundamental achievement that he won a Nobel Prize in chemistry for it just 5 years later.
"The role of channels in the body is so critical that we would not be alive were it not for the vigilance of these gateways in maintaining healthy cells. NIH-supported research in this area will no doubt continue to deepen understanding of the molecular roots of disease as well as fuel the discovery of new medicines to treat a wide variety of health disorders."
ï¿½Elias A. Zerhouni, Former Director, National Institutes of Health
October 8, 2003
NOBEL QUICK FACTS
ï¿½ ï¿½ The Nobel Foundation
The Nobel Prize was created by Swedish inventor Alfred Nobel. The international award has been given yearly since 1901 for achievements in physics, chemistry, physiology or medicine, literature and peace. Another category, economics, was added by the Nobel Foundation in 1968. Winners receive their awards on December 10, the anniversary of Nobel's death. For more facts about the Nobel Prize, visit http://www.nobelprize.org/nobel_prizes/facts/.
Want to know more about NIGMS and the award-winning researchers it funds? Visit http://www.nigms.nih.gov.
NIGMS is a part of the National Institutes of Health that supports basic research to increase our understanding of life processes and lay the foundation for advances in disease diagnosis, treatment and prevention. For more information on the Institute's research and training programs, visit http://www.nigms.nih.gov.
Content revised October 2013